Post Mon Jan 20, 2020 5:59 pm

Senior Scientist open position Stanford University

The Fantl Lab at Stanford University School of Medicine studies human tumors with translational endpoints with the over-arching goal to dramatically shorten the time from bench to bedside. We use multi-parameter single cell technologies (mass cytometry/CyTOF and imaging) to comprehensively characterize human tumors on a cell-by-cell basis; specifically ovarian, kidney and prostate. Two areas of focus of the lab are tumor-immune interactions and the DNA-damage response. To date, work from our and other labs have demonstrated that multi-parameter single cell technologies have provided an unprecedented level of mechanistic detail not only revealing further unappreciated complexity of tumor ecosystems, but directing us toward more meaningful novel biomarkers. These are highly likely to guide far more beneficial treatment regimens for cancer patients. We work collaboratively in multidisciplinary teams. We synergize with bioinformaticians for integrating large data-sets and clinicians to ensure the acquisition of tumor tissue and also to keep us on track as to what will make a difference to patients.
We are seeking a highly motivated, committed and creative Senior Scientist to oversee the general running of the lab. The preferred candidate is an immunologist and/or cancer biologist. The candidate will be adept at working with multiple assay formats, assay troubleshooting, problem-solving and data analysis/interpretation in addition to driving multiple research projects
He/she will apply CyTOF to clinically annotated tumors and blood samples and use integrative computational tools to provide novel insight about disease mechanism and develop potential biomarkers. Projects include, but are not limited to: i) therapeutic resistance in ovarian cancer ii) predictive biomarkers for women with ovarian cancer likely to respond to PARPis iii) understanding the role of defects in BRCA1/2 and other DNA damage response genes with the tumor immune infiltrate in ovarian cancer iv) predicting response of renal cell carcinoma patients to immunotherapy v) determining which men with localized prostate cancer will develop aggressive disease.
Educational Requirements:
PhD Biological Sciences, Immunology, Molecular Biology, Genetics, or related field of study.
Skills required:
Flow cytometry and mass cytometry, processing clinical samples especially those obtained from prospective clinical trials, cell culture; cell lines and primary cells, transfection, immunohistochemistry, general techniques in molecular biology, knowledge of rudimentary data analysis. Must have exemplary organizational skills, clear written and oral communication skills, ability to learn new techniques and be familiar with day-to-day running of lab.

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