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181-Tantalum Conjugation

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Jahangir

Contributor

Posts: 37

Joined: Sun Oct 29, 2017 6:34 pm

Post Mon Mar 19, 2018 3:54 pm

181-Tantalum Conjugation

Hi all,

Hope everyone is well.

Just wondered if anyone tried conjugating antibodies to this metal - the Tantalum-181. You can buy it from Sigma in the (V) Chloride format -> https://www.sigmaaldrich.com/catalog/su ... &region=GB, at a really good purity as well. Just not too sure if (V) Chloride metals will conjugate to antibodies - or if the actual metal is dangerous, etc.

Any information will be much appreciated!!

Jahangir
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PrfromTexas

Participant

Posts: 1

Joined: Fri Nov 16, 2018 9:45 am

Location: Cibolo, Texas

Post Mon Nov 19, 2018 8:30 am

Re: 181-Tantalum Conjugation

Hello,

For the last few weeks, I've been concentrating on the research based on Platinum-conjugated Antibodies for Application in Mass Cytometry (studying aspects in mass cytometry). We are planning to start working with Chloride metals (Platinum(IV) chloride and Tantalum(V) chloride) in December (the first laboratory group meeting is scheduled on December 15). In case I have some valid information, I can update you, if you are still interested.
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MCOlivier

Contributor

Posts: 32

Joined: Mon Oct 05, 2015 9:48 am

Location: European Genomic Institute for Diabetes, Universitity of Lille, Institut Pasteur de Lille, France

Post Wed Nov 21, 2018 8:54 am

Re: 181-Tantalum Conjugation

Hello,

I will be very interested if you have some positive results with this Isotope conjugation !
Would you precize with which polymer you are tempting it ?

Regards
Olivier
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Yefeng

Participant

Posts: 1

Joined: Fri Mar 13, 2020 2:25 pm

Post Fri Apr 03, 2020 4:36 pm

Re: 181-Tantalum Conjugation

Jahangir wrote:Hi all,

Hope everyone is well.

Just wondered if anyone tried conjugating antibodies to this metal - the Tantalum-181. You can buy it from Sigma in the (V) Chloride format -> https://www.sigmaaldrich.com/catalog/su ... &region=GB, at a really good purity as well. Just not too sure if (V) Chloride metals will conjugate to antibodies - or if the actual metal is dangerous, etc.

Any information will be much appreciated!!

Jahangir

Hi Jahangir,

We recently developed a tantalum oxide NP based mass tag for MC applications. See attached link: https://pubs.acs.org/doi/10.1021/acs.analchem.9b04970

Yefeng

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