Fri Mar 02, 2018 3:57 pm by mleipold
Hi Naeem,
What marker do you have on 148? What is its signal intensity?
The reason I ask: there are a number of Nd isotopes, and yes, some of them that you get from Fluidigm are "cleaner" than others, but that is an issue of isotopic purity (eg, Nd146 in your Nd145 stock). However, no one Nd isotope oxidizes more or less than the other Nd isotopes: on a per atom basis, Nd148 and Nd142 should oxidize the same amount.
However, any sort of spillover, including oxide/M+16, is proportional to signal intensity at mass M. Therefore, if you have a really abundant marker at M (eg, CD45, CD57, etc) with a signal intensity into the high 100s-mid 1000s Dual, then you'll have a lot more spill in M+16. But that's a panel design issue, not something inherent to Nd148 specifically.
Mike