Re: Verity Cen-se?
In theory, it would be very tough to prove that this method captures close to all phenotypic data possible, with little to no bias, because one might ask what would make our best biological standard? Does this standard cover everything? Still, the evidence Bagwell shows regarding the difference in DNA-Ir signal between different cell populations gives us a real benchmark to compare "manual" (and dare I say?) "pulse" gating techniques. Say we deplete a sample of myeloid cells, and spike in a known amount, to see how accurate the two gating methods are (...for example)?
Without a doubt, this would be a *fun* publication to write.
Best,
Matthew