Post Wed Aug 10, 2022 5:53 pm

2022-Herdlevær et al-Biomarkers of the Tumor Microenvironmen

"Use of Imaging Mass Cytometry in Studies of the Tissue Microenvironment"
Herdlevær, I., Petrilli, L.L., Qosaj, F., Vinci, M., Bressan, D., Gavasso, S.
Biomarkers of the Tumor Microenvironment, 2022 345–364
https://doi.org/10.1007/978-3-030-98950-7_20

- review of IMC

- I'm a little puzzled by this statement:
"The spatial heterogeneity of tumour marker expression in breast cancer biopsies has recently been demonstrated using multiplexed ion beam imaging (MIBI), another platform under the umbrella of spatial proteomics [15, 54]. Though MIBI permits higher resolution imaging than IMC, it lacks the remarkable multiplexing capacity inherent to IMC and is further limited by the matrix required for sample embedding."
- I'm not sure what the authors mean by MIBI lacking "the remarkable multiplexing capacity inherent to IMC"......