Page 1 of 1

Reg:T cell exhaustion markers

PostPosted: Tue Dec 08, 2020 6:14 am
by komal2000
Hi All,

I am studying different immune cell populations using Deep Immune Profiling kit 30 markers. Also interested in looking at possible exhausted T cells but I don't have specific markers to look at exhausted T cells in this kit. I believe there are few antibodies in this kit can able to identify T cell exhaustion. If you have any experience or suggestion on gating to identifying T cell exhaustion using this kit would be very helpful. Please, take a look at the attached screenshot for more details on the kit I am using.



Sincerely
Komal

Re: Reg:T cell exhaustion markers

PostPosted: Tue Dec 08, 2020 3:07 pm
by singh423
Hi
In my knowledge other than CD57 , I am afraid to say this panel have T cells exhaustion markers.

Re: Reg:T cell exhaustion markers

PostPosted: Thu Dec 10, 2020 11:26 am
by bbengsch
The panel is not suitable for profiling T cell exhaustion without modification. I would also argue that CD57 is not per se informative for exhausted cells, even though some exhausted cells can express it. We have summarized our thoughts on choice of exhaustion markers in more detail in this open access review: https://pubmed.ncbi.nlm.nih.gov/32038613/