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Reg:T cell exhaustion markers

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komal2000

Participant

Posts: 15

Joined: Mon Aug 29, 2016 12:55 pm

Location: University of Helsinki, Finland

Post Tue Dec 08, 2020 6:14 am

Reg:T cell exhaustion markers

Hi All,

I am studying different immune cell populations using Deep Immune Profiling kit 30 markers. Also interested in looking at possible exhausted T cells but I don't have specific markers to look at exhausted T cells in this kit. I believe there are few antibodies in this kit can able to identify T cell exhaustion. If you have any experience or suggestion on gating to identifying T cell exhaustion using this kit would be very helpful. Please, take a look at the attached screenshot for more details on the kit I am using.



Sincerely
Komal
Attachments
Screen Shot 2020-12-08 at 8.05.56.png
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singh423

Participant

Posts: 5

Joined: Mon Feb 12, 2018 10:42 pm

Post Tue Dec 08, 2020 3:07 pm

Re: Reg:T cell exhaustion markers

Hi
In my knowledge other than CD57 , I am afraid to say this panel have T cells exhaustion markers.
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bbengsch

Participant

Posts: 2

Joined: Thu Jun 19, 2014 12:39 pm

Post Thu Dec 10, 2020 11:26 am

Re: Reg:T cell exhaustion markers

The panel is not suitable for profiling T cell exhaustion without modification. I would also argue that CD57 is not per se informative for exhausted cells, even though some exhausted cells can express it. We have summarized our thoughts on choice of exhaustion markers in more detail in this open access review: https://pubmed.ncbi.nlm.nih.gov/32038613/

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