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Lanthanides in biology

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mleipold

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Location: Stanford HIMC, CA, USA

Post Mon Aug 19, 2019 3:46 pm

Lanthanides in biology

Hi all,

I've posted once or twice about lanthanide-containing enzymes in biology. So far they haven't come up in our assays: there aren't any known cases in mammals, and very little CyTOF work has been done (so far) on bacteria, etc.

Just in case anyone is interested in reading more, though, here's a recent minireview (and references therein):
"Essential and Ubiquitous: The Emergence of Lanthanide Metallobiochemistry"
https://doi.org/10.1002/anie.201904090


Mike
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mleipold

Guru

Posts: 5792

Joined: Fri Nov 01, 2013 5:30 pm

Location: Stanford HIMC, CA, USA

Post Wed Sep 25, 2019 5:48 pm

Re: Lanthanides in biology

"The Chemistry of Lanthanides in Biology: Recent Discoveries, Emerging Principles, and Technological Applications"
https://doi.org/10.1021/acscentsci.9b00642
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mleipold

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Posts: 5792

Joined: Fri Nov 01, 2013 5:30 pm

Location: Stanford HIMC, CA, USA

Post Wed Nov 24, 2021 9:04 pm

Re: Lanthanides in biology

Digest:
"A Natural Lanthanide-Binding Protein Facilitates Separation and Recovery of Rare Earth Elements"
https://doi.org/10.1021/acscentsci.1c01247

Full article:
"Bridging Hydrometallurgy and Biochemistry: A Protein-Based Process for Recovery and Separation of Rare Earth Elements"
https://doi.org/10.1021/acscentsci.1c00724

- interesting use of citrate to help strip high-mass lanthanides over low-mass lanthanides: "These studies, using titrations with LanM bound to individual REEs, revealed that citrate selectively outcompeted LanM for HREEs before LREEs, as expected given LanM’s apparent Kd’s (Figure 3B). For example, 10 mM citrate is sufficient to fully desorb Dy from LanM, whereas Nd is still mostly bound to the protein."


-Related:
"Unlocking the Lanthanome"
https://doi.org/10.1021/acscentsci.1c01357

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